H-Ile-Trp-OH
CAS No. : 13589-06-5
(Synonyms: Ile-Trp)
Price and Availability of
CAS No. : 13589-06-5
| Size | Price | Stock |
|---|---|---|
| 10mg | $30 | In-stock |
| 25mg | $55 | In-stock |
| 50mg | $85 | In-stock |
| 100mg | $125 | In-stock |
| 500mg | $300 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-105858 |
| M.Wt: | 317.38 |
| Formula: | C17H23N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Introduction of
13589-06-5
:
H-Ile-Trp-OH (Ile-Trp), a dipeptide, is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.7 μM. H-Ile-Trp-OH inhibits predominantly the C-domain of ACE[1].
IC50 & Target:α7 nAChR[1].
In Vivo:H-Ile-Trp-OH (0.1-10 mg/kg) increases the time spent and the distance travelled in the open arms of the maze in mice[4].
Mean pharmacokinetic parameters following oral administration of H-Ile-Trp-OH to male Sprague Dawley rats at doses of 0.5, 5 and 100 mg/kg[3]
| Parameter | Measured Dose (mg/kg) | Apparent thalf (h) | Cmax (μM) | Tmax (min) | AUC0-tlast (μM*min) | AUC0-inf (μM*min) | AUC0-inf/D (μM*min*kg/μmol) | Apparent BA (%) | % Dose in urine |
| 0.5 mg/kg | 0.55 | c.n.c. | 0.2 | 30 | 53.8 | c.n.c. | 41.4 | 66.7 | 1.6 |
| 5 mg/kg | 4.8 | 8.8 | 1.1 | 30/300/30 | 496.8 | 497.6 | 43.7 | 70.3 | 0.7 |
| 100 mg/kg | 102.4 | 6.3 | 5.7 | 150 | 3055.1 | 3062.9 | 12.5 | 13.2 | 0.2 |