BRD-K98645985
CAS No. : 1357647-78-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $500 | In-stock |
| 5mg | $1800 | In-stock |
| 10mg | $2950 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-114268 |
| M.Wt: | 573.73 |
| Formula: | C33H43N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity[1].
In Vitro: BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4[1].
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting[1].
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