AZD4320
CAS No. : 1357576-48-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $83 | In-stock |
| 5mg | $175 | In-stock |
| 10mg | $245 | In-stock |
| 25mg | $515 | In-stock |
| 50mg | $825 | In-stock |
| 100mg | $1450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112416 |
| M.Wt: | 945.53 |
| Formula: | C45H48ClF3N4O7S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. IC50 & Target: [1]IC50: 26 nM (KPUM-MS3 cells), 17 nM (KPUM-UH1 cells),170 nM (STR-428 cells) [1] In Vitro: AZD4320 potently augments the antitumor effect of AZD5153 (Cat. No.: HY-100653A) in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines, and profoundly increases cells undergoing apoptosis in all three cell lines[1].
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