Palonosetron
CAS No. : 135729-61-2
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| Cat. No. : | HY-A0018 |
| M.Wt: | 296.41 |
| Formula: | C19H24N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Palonosetron is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. Palonosetron exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron also possesses antidepressant activity[1][2][3][4]. In Vitro:Palonosetron (10 nM, 2 hours) inhibits the enhancement effect of 5-HT on substance P (SP)-induced calcium release in NG108-15 cells, increasing the EC50 of SP from 0.62 µM to 3.7 µM[6]. In Vivo:Palonosetron (0.05 mg/kg, i.p., single dose) significantly reduces immobility in Swiss albino mice, demonstrating potential antidepressant activity[5]. alonosetron (30-300 µg/kg, i.v., single dose) dose-dependently inhibits SP-mediated neuronal responses in the Cisplatin (HY-17394)-induced rat emesis model, indicating its impact on neurotransmission[6].
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