ML228
CAS No. : 1357171-62-0
(Synonyms: CID-46742353)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $188 | In-stock |
| 25mg | $355 | In-stock |
| 50mg | $533 | In-stock |
| 100mg | $800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12754 |
| M.Wt: | 415.49 |
| Formula: | C27H21N5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 35 mg/mL |
ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2]. IC50 & Target:EC50: 1 μM (HIF)[1] In Vitro:ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications[1][2]. In Vivo:ML228 (injection; 1 μg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function[3].
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