Ischemin
CAS No. : 1357059-00-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $175 | In-stock |
| 25mg | $348 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-110315A |
| M.Wt: | 335.38 |
| Formula: | C15H17N3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1].
In Vitro:Ischemin (50, 100 µM; 24 h) inhibits p53 activation on DNA damaging stress in U2OS cells[1].
Ischemin (10 μM; 3 days) blocks apoptosis in cardiomyocytes by inhibiting caspase 3/7 activity[1].
Ischemin inhibits p53 cellular signaling pathways in U2OS cells[1].
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