AZD-3463
CAS No. : 1356962-20-3
(Synonyms: ALK/IGF1R inhibitor)
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $183 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $495 | In-stock |
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| Cat. No. : | HY-15609 |
| M.Wt: | 448.95 |
| Formula: | C24H25ClN6O |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells[1][2][3].
In Vitro:AZD-3463 (0-50 µM; 72 h) suppresses the viability and proliferation of both wild type and mutant ALK NB cells[1].
AZD-3463 (10 µM; 0-4 h) effectively inhibits ALK-mediated PI3K/AKT/mTOR signaling and induces apoptosis and autophagy in NB cells[1].
AZD-3463 (0-100 nM; 4 h) inhibits FLT3-ITD-mediated activation of AKT, ERK1/2 and p38 in a dose-dependent manner in MOLM-13 and MV4-11 cells[2].
In Vivo:AZD3463 (15 mg/kg; i.p.; once daily for 2 days) inhibits tumor growth in different orthotopic NB xenograft mouse models[1].
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