CNDAC
CAS No. : 135598-68-4
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| Cat. No. : | HY-16445A |
| M.Wt: | 252.23 |
| Formula: | C10H12N4O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis[1][2].
In Vitro:CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) when cells go through a second S phase[1].
Lack of Rad51D and XRCC3 sensitizes cells to CNDAC (0-1 μM; 24 h)[1].
CNDAC (0-100 μM; 3 days) inhibits proliferation of HL-60 and THP-1 cells[2].
CNDAC (0-10 μM; 3-6 days) induces apoptosis in HL-60 and THP-1 cells[2].
CNDAC (6 μM; 48 h) induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells[3].
In Vivo:CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4].
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