DSR-71167
CAS No. : 1355687-91-0
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| Cat. No. : | HY-120321 |
| M.Wt: | 529.96 |
| Formula: | C23H23ClF3N3O4S |
| Purity: | >98 % |
| Solubility: |
DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].
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