ML309
CAS No. : 1355446-05-7
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| Cat. No. : | HY-121916 |
| M.Wt: | 484.56 |
| Formula: | C29H29FN4O2 |
| Purity: | >98 % |
| Solubility: |
ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer[1].
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