LY 254155
CAS No. : 135503-67-2
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| Cat. No. : | HY-14523 |
| M.Wt: | 449.48 |
| Formula: | C19H23N5O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively. IC50 & Target:Ki: 2.1±0.2 (hGARFT ), 1.7± 0.1 nM (mFBP)[1] In Vitro:LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) [1]. In Vivo:LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively[1].
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