CYM50260
CAS No. : 1355026-60-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $490 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-108494 |
| M.Wt: | 350.60 |
| Formula: | C14H11Cl3FNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].
IC50 & Target: EC50: 45 nM (S1P4-R)[1]
In Vitro: CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1].
CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].
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- HY-108494
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