Naloxegol (oxalate)
CAS No. : 1354744-91-4
(Synonyms: NKTR-118 (oxalate); AZ-13337019 (oxalate))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $70 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $225 | In-stock |
| 100mg | $360 | In-stock |
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| Cat. No. : | HY-A0118A |
| M.Wt: | 741.82 |
| Formula: | C36H55NO15 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is an orally active peripherally acting μ-opioid receptor antagonist with a target Ki of 7.42 nM. Naloxegol oxalate inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract, and alleviates opioid-induced gastrointestinal hypomotility, delayed transit, hypertonicity, and increased fluid reabsorption. Naloxegol oxalate is applicable to research related to opioid-induced constipation[1][2]. IC50 & Target:Opioid receptor[1] In Vitro:Naloxegol oxalate binds with high affinity to μ-opioid receptors and κ-opioid receptors and low affinity to δ-opioid receptors in vitro, with no significant activity at non-opioid targets[2]. In Vivo:Naloxegol oxalate inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract, and alleviates the opioid-induced phenomena including slowed gastrointestinal motility and transit, hypertonicity, and increased fluid reabsorption[2].
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