PDE10A-IN-1
CAS No. : 1354404-30-0
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| Cat. No. : | HY-120945 |
| M.Wt: | 369.42 |
| Formula: | C23H19N3O2 |
| Purity: | >98 % |
| Solubility: |
PDE10A-IN-1 is a phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 250 nM and the ability to cross the blood-brain barrier. PDE10A-IN-1 can be used in research on neurological disorders such as schizophrenia[1].
In Vitro:PDE10A-IN-1 (Compound 8) (2 µM) inhibits PDE10A enzyme (IC50 = 250 nM)[1].
PDE10A-IN-1 exhibits metabolic stability in human liver microsomes with an HLM Clint of 1.1 L/min[1].
In Vivo:PDE10A-IN-1 exhibits in vivo antipsychotic activity in Rats (Schizophrenia model) (with a ED50 of 60 mg/kg)[1].
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