ACT-335827
CAS No. : 1354039-86-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $730 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-108683 |
| M.Wt: | 518.64 |
| Formula: | C31H38N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 51.864 mg/mL (ultrasonic);Ethanol : 51.864 mg/mL (ultrasonic) |
ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders[1].
In Vitro: ACT-335827 (0-10 μM, 2 h) acts on OXR-1 and OXR-2 with the Kb values of 41 nM and 560 nM, the IC50 values of 120 nM and 2300 nM, respectively in CHO cells[1].
In Vivo: ACT-335827 (oral gavage, 30-100 mg/kg, once) can reduce the fear-induced startle response with no affecting motor or cognitive function in rats[1].
ACT-335827 (oral administration, 300 mg/kg, everyday, 4 weeks) has less effect on metabolic syndrome (MetS), such as diet-induced obesity (DIO) in male Wistar rats[2].
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