Longdaysin
CAS No. : 1353867-91-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $144 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $690 | In-stock |
| 200mg | $965 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-18285 |
| M.Wt: | 335.33 |
| Formula: | C16H16F3N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively[1][2].
IC50 & Target:IC50: 5.6 µM (CK1α), 8.8 µM (CK1δ), 29 µM (CDK7), 52 µM (ERK2)[2]
In Vitro:Longdaysin (0-9 µM; 1 week) lengthens circadian period in adult tail fibroblasts, lung explants, and SCN explants from mPer2Luc knockin mice[2].
Longdaysin (0-25 µM; 1 week ) inhibits the colony formation, migration, invasion, and sphere formation of breast cancer Hs578T or MDA-MB-231 cells[3].
Longdaysin (0-50 µM; 24 h) inhibits Wnt/β-catenin signaling by inhibition of CK1δ and CK1ε in HEK293T cells[3].
In Vivo:Longdaysin (0-9 µM; 1 week) increases circadian period in zebrafish[2].
Longdaysin (5 mg/kg, i.p., every 3 days for 3 weeks) inhibits tumor growth in MDA-MB-231 xenografts mice[3].
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