CX-6258 (hydrochloride hydrate)
CAS No. : 1353858-99-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $144 | In-stock |
| 10mg | $192 | In-stock |
| 25mg | $384 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $756 | In-stock |
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| Cat. No. : | HY-18095A |
| M.Wt: | 516.42 |
| Formula: | C26H27Cl2N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : 7.14 mg/mL (ultrasonic;warming;heat to 60°C) |
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1].
IC50 & Target: IC50: 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)[1]
In Vitro: CX-6258 causes dose dependent inhibition of the phosphorylation of two pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively[1].
CX-6258 treatment (12 mM, 3 h) treatment diminishes steady-state levels of ectopic NKX3.1 in PC3 cells[2].
CX-6258 treatment results in a significant reduction in NKX3.1 half-life[2].
In Vivo: CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models[1].
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