CSRM617 (hydrochloride)
CAS No. : 1353749-74-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-122611A |
| M.Wt: | 291.69 |
| Formula: | C10H14ClN3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1] In Vitro: CSRM617 (0.01-100 μM; 48 hours) hydrochloride inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1]. CSRM617 (10-20 μM; 48 hours) hydrochloride induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1]. CSRM617 (20 μM; 72 hours) hydrochloride induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1]. In Vivo: CSRM617 (50 mg/kg; p.o.; daily, for 20 d) inhibits tumor growth in SCID mice with 22Rv1 xenograft[1].
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