AUNP-12
CAS No. : 1353563-85-5
(Synonyms: NP-12)
| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | In-stock |
| 5mg | $340 | In-stock |
| 10mg | $560 | In-stock |
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| Cat. No. : | HY-P1812 |
| M.Wt: | 3261.55 |
| Formula: | C142H226N40O48 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic) |
AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].
IC50 & Target:PD-1 signaling pathway[1]
In Vitro: AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1].
AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1].
AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1].
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