Olmutinib
CAS No. : 1353550-13-6
(Synonyms: HM61713; BI 1482694)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $106 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $238 | In-stock |
| 100mg | $370 | In-stock |
| 200mg | $594 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-19730 |
| M.Wt: | 486.59 |
| Formula: | C26H26N6O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Olmutinib (HM61713; BI-1482694) is an orally active and irreversible third EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib is used for NSCLC[1][2]. IC50 & Target:IC50: 9.2 nM (HCC827) and 10 nM (H1975) [1] In Vitro: Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].
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