RP-54745
CAS No. : 135330-08-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $128 | In-stock |
| 10mg | $205 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $525 | In-stock |
| 100mg | $656 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101716 |
| M.Wt: | 297.82 |
| Formula: | C13H12ClNOS2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. In Vitro: RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1]. In Vivo: RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745[2].
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