Men 10376
CAS No. : 135306-85-3
(Synonyms: Neurokinin-2 receptor antagonist)
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| Cat. No. : | HY-P1276 |
| M.Wt: | 1081.22 |
| Formula: | C57H68N12O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in H2O |
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. IC50 & Target:Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] In Vitro:Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. In Vivo:Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
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