MIV-247
CAS No. : 1352817-76-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $900 | Get quote |
| 10mg | $1450 | Get quote |
| 25mg | $3050 | Get quote |
| 50mg | $4870 | Get quote |
| 100mg | $7800 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112583 |
| M.Wt: | 391.39 |
| Formula: | C17H24F3N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. IC50 & Target:IC50: 2.1 nM (Human Cathepsin S), 4.2 nM (Mouse Cathepsin S), 7.5 nM (Cynomolgus monkey Cathepsin S)[1] In Vivo:Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions[1].
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