Navtemadlin
CAS No. : 1352066-68-2
(Synonyms: AMG 232; KRT-232)
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $560 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1520 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12296 |
| M.Wt: | 568.55 |
| Formula: | C28H35Cl2NO5S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
IC50 & Target: IC50: 0.6 nM (p53-MDM2 interaction)[1]
Kd: 0.045 nM (MDM2)[1]
In Vitro: Navtemadlin (AMG 232) (10 μM) induces p53 signaling and inhibits tumor cell proliferation in three p53 wild-type tumor cell lines[1].
Navtemadlin potently inhibits proliferation of non-MDM2-amplified HCT116 colorectal cells (IC50=10 nM)[3].
In Vivo: Navtemadlin (AMG 232) (10, 25, 75 mg/kg, once daily, p.o.) activates p53 pathway activity in vivo[1].
Navtemadlin (10, 25, 75 mg/kg, once daily, p.o.) potently inhibits growth of tumor xenografts in mice[1].
Navtemadlin (10, 25, 75 mg/kg, once daily, p.o.) blocks DNA synthesis and induces apoptosis in vivo[1].
Navtemadlin causes a dose-dependent tumor growth inhibition with an ED50 of 16 mg/kg[2].
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