OSU-2S
CAS No. : 1351056-65-9
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| Cat. No. : | HY-117720 |
| M.Wt: | 335.52 |
| Formula: | C21H37NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].
In Vitro:OSU-2S (1.25, 2.5 µM; 48 h) decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201) (2.5, 5 µM)[1].
OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) combinantion inhibits cell proliferative and migration[1].
OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) decreases the expression of PARP in a dose and time-dependent manner in Hep3B cells[2].
OSU-2S (5 µM; 12, 24 h) induces apoptosis in Hep3B cells[2].
OSU-2S (0-10 µM; 1 h) stimulates ROS production in a dose-dependent manner in Hep3B, Huh7, PLC-5 cells[2].
In Vivo:OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) suppresses the tumor growth in mouse[2].
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