GS-6620
CAS No. : 1350735-70-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $850 | In-stock |
| 5mg | $2115 | In-stock |
| 10mg | $3385 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-12633 |
| M.Wt: | 644.61 |
| Formula: | C29H37N6O9P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV)[1][2].
IC50 & Target:IC50: 48-680 nM (HCV replicons of genotypes 1 to 6)[1]
In Vitro:GS-6620 (72 h) inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM and shows weak activity against bovine viral diarrhea virus (BVDV, EC50 = 1.5 μM)[1].
GS-6620 (active metabolite) (0.39-1.3 μM, 70-90 mins) inhibits HCV NS5B polymerase[1].
GS-6620 (0-100 μM, 5 days) shows low cytotoxicity in Huh-7, HepG2, PC-3 and PBMCs with CC50 values of 67, 66, 40 and >100 μM[1].
GS-6620 (20-100 μM, 5-10 days) does not reduce mitochondrial DNA content in HepG2 cells or inhibit mitochondrial protein synthesis in PC-3 cells[1].
In Vivo:GS-6620 (1000 mg/kg for rats or 60 mg/kg for dogs, i.g., daily for 26-39 weeks) exerts no adverse effects in SD rats and beagle dogs[1].
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