SKLB188


CAS No. : 1350545-09-3

1350545-09-3
Price and Availability of CAS No. : 1350545-09-3
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Cat. No. : HY-120412
M.Wt: 513.59
Formula: C27H31N9O2
Purity: >98 %
Solubility:
Introduction of 1350545-09-3 :

SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors[1].

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