(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CAS No. : 135042-17-0
| Size | Price | Stock |
|---|---|---|
| 1g | $15 | In-stock |
| 5g | $22 | In-stock |
| 10g | $27 | In-stock |
| 25g | $56 | In-stock |
| 100g | $223 | In-stock |
| 500g | $1114 | In-stock |
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| 2 kg | Get quote | |
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| Cat. No. : | HY-W017882 |
| M.Wt: | 245.27 |
| Formula: | C11H19NO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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- (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
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