N-Boc-cis-4-Hydroxy-D-proline
CAS No. : 135042-12-5
| Size | Price | Stock |
|---|---|---|
| 5g | $13 | In-stock |
| 10g | $16 | In-stock |
| 25g | $25 | In-stock |
| 100g | $95 | In-stock |
| 500g | $474 | In-stock |
| 1000g | $757 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W002887 |
| M.Wt: | 231.25 |
| Formula: | C10H17NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.
In Vitro:ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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