(S)-JQ-35


CAS No. : 1349719-98-7

(Synonyms: TEN-010)

1349719-98-7
Price and Availability of CAS No. : 1349719-98-7
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5mg $150 In-stock
10mg $240 In-stock
25mg $450 In-stock
50mg $750 In-stock
100mg $1200 In-stock
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Cat. No. : HY-117286
M.Wt: 540.12
Formula: C27H34ClN7OS
Purity: >98 %
Solubility: DMSO : ≥ 85 mg/mL
Introduction of 1349719-98-7 :

(S)-JQ-35 (TEN-010) is an orally active, blood-brain barrier-permeable bromodomain inhibitor that selectively targets the bromodomain and extra-terminal domain (BET) protein family (BRD4, BRD3, BRD2 and BRDT). (S)-JQ-35 blocks the activation of Myc gene expression by BRD4, thereby inhibiting cancer cell proliferation and promoting cancer cell apoptosis. (S)-JQ-35 can be used in research related to NUT midline carcinoma and neuroblastoma[1][2]. In Vitro:(S)-JQ-35 (72 h) inhibits the viability of 15 neuroblastoma cell lines, with IC50 values ranging from 85 nM to 4.8 μM[2].

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