Propargyl-PEG4-thiol
CAS No. : 1347750-80-4
| Size | Price | Stock |
|---|---|---|
| 100mg | $531 | Get quote |
| 250mg | $781 | Get quote |
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| 1 g | Get quote | |
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| Cat. No. : | HY-116427 |
| M.Wt: | 248.34 |
| Formula: | C11H20O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG4-thiol is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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