G-744
CAS No. : 1346669-54-2
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| Cat. No. : | HY-102036 |
| M.Wt: | 527.64 |
| Formula: | C29H29N5O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1]. IC50 & Target: IC50: 2 nM (Btk), 64 nM (CD86)[1]. In Vivo: G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently[1].
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