GSK621
CAS No. : 1346607-05-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $135 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $640 | In-stock |
| 100mg | $990 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100548 |
| M.Wt: | 489.91 |
| Formula: | C26H20ClN3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;adjust pH to 1 with HCl) |
GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation[1].
In Vitro: GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation[1].
GSK621 (30 μM) induces autophagy and apoptosis[1].
GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells[1].
In Vivo: GSK621 (30 mg/kg, ip twice daily) exhibits significant anti-tumor activity in MOLM-14 cells xenograft[1].
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