IPI-9119
CAS No. : 1346564-56-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $720 | In-stock |
| 25mg | $1150 | In-stock |
| 50mg | $1600 | In-stock |
| 100mg | $2560 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124628 |
| M.Wt: | 495.43 |
| Formula: | C24H19F2N5O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
IPI-9119 is an orally active, selective and irreversible FASN inhibitor with an IC50 of 0.3 nM in vitro biochemical assay. IPI-9119 inhibits tumor growth of castration-resistant prostate cancer (CRPC) xenografts mouse models[1][2].
IC50 & Target:IC50: 0.3 nM (FASN)[1]
In Vitro:IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM), and shows more than 400-fold selectivity against several additional serine hydrolases[2].
IPI-9119 (0.1-0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest, apoptosis[1].
IPI-9119 (0.05-5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression[1].
In Vivo:IPI-9119 (SC pump infusion; 0.5 μL/h; 100 mg/mL; for 28 days) inhibits tumor growth of CRPC xenografts mouse models[1].
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