GSK-872
CAS No. : 1346546-69-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $42 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $600 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101872 |
| M.Wt: | 383.49 |
| Formula: | C19H17N3O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury[1][2][3]. IC50 & Target: IC50: 1.3 nM (RIPK3)[1] In Vitro: GSK-872 (GSK'872; 0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in human HT-29 cells in a concentration-dependent manner[1]. In Vivo: GSK-872 (25 mM; intracerebroventricular injection) can attenuate brain edema and improve neurological function following subarachnoid hemorrhage (SAH) and reduce the number of necrotic cells. GSK-872 can also decrease the protein levels of RIPK3 and MLKL, and cytoplasmic translocation and expression of HMGB1, an important pro-inflammatory protein[3].
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