JNJ-42165279
CAS No. : 1346528-50-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $620 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19636 |
| M.Wt: | 410.80 |
| Formula: | C18H17ClF2N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
JNJ-42165279 is an orally active FAAH inhibitor, with IC50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain[1][2]. In Vitro: JNJ-42165279 (10 μM, 1 hour) exhibited high selectivity and inhibitory activity against human and rat FAAH enzymes[1]. In Vivo: JNJ-42165279 (60 mg/kg, p.o., single dose) effectively alleviated neuropathic pain in the spinal nerve ligation (SNL)-induced neuropathic pain rat model[2]. High-dose JNJ-42165279 (100 mg/kg, p.o., once daily for 11 days) induced degenerative lens changes and cataracts in the embryo-fetal development process in Sprague-Dawley rats[2].
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