K-8012
CAS No. : 1346513-17-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $420 | In-stock |
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| Cat. No. : | HY-121435 |
| M.Wt: | 374.45 |
| Formula: | C23H23FN4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
K-8012, a sulindac (HY-B0008) analog, is a potent antagonist of RXRa. The IC50 value for K-8012 to inhibit 9-cis-RA-induced Gal4-RXRa-LBD trans-activation were about 9.2 μM. K-8012 exerts improved anticancer activity over sulindac in a RXRa-dependent manner. K-8012 exhibits activity in inhibiting the tRXRa-mediated PI3K/AKT signaling pathway. K-8012 induces apoptosis and inhibits AKT activation by preventing tRXRa from binding to p85a[1].
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