3-O-Methyltolcapone
CAS No. : 134612-80-9
(Synonyms: Ro 40-7591)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $35 | In-stock |
| 25mg | $65 | In-stock |
| 50mg | $125 | In-stock |
| 100mg | $200 | In-stock |
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| Cat. No. : | HY-100642 |
| M.Wt: | 287.27 |
| Formula: | C15H13NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4][5][6].
IC50 & Target:COMT[1][2]
In Vitro:3-O-Methyltolcapone (1-10 μM, 18 h) stabilizes TTR tetramers in human plasma and reduces monomer formation[1].
3-O-Methyltolcapone binds to TTR with a Kd value of 33 nM[1].
3-O-Methyltolcapone (0.1-500 μM, 48 h) shows significantly lower toxicity in neuronal and hepatic cells and SH-SY5Y neuroblastoma cells[1].
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