ONO4057
CAS No. : 134578-96-4
(Synonyms: ONO-LB457)
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| Cat. No. : | HY-U00252 |
| M.Wt: | 470.55 |
| Formula: | C27H34O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM. IC50 & Target: IC50: 0.7±0.3 μM (Leukotriene B4 receptor)[1] In Vivo: Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].
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