Atorvastatin (sodium)
CAS No. : 134523-01-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $53 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $440 | In-stock |
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| Cat. No. : | HY-108257 |
| M.Wt: | 580.62 |
| Formula: | C33H34FN2NaO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5]. In Vitro:Atorvastatin sodium decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4]. In Vivo:Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) sodium significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin sodium treatment[5].
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