Atorvastatin
CAS No. : 134523-00-5
| Size | Price | Stock |
|---|---|---|
| 10mg | $55 | In-stock |
| 50mg | $77 | In-stock |
| 100mg | $132 | In-stock |
| 200mg | $220 | In-stock |
| 500mg | $418 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-B0589 |
| M.Wt: | 558.64 |
| Formula: | C33H35FN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3]. In Vitro: Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4]. In Vivo: Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE / mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].
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