Ro 0437626
CAS No. : 134362-79-1
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| Cat. No. : | HY-108673 |
| M.Wt: | 525.66 |
| Formula: | C27H35N5O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1]. IC50 & Target: IC50: 3 μM (P2X1 receptor) In Vitro: Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control[2]. In Vivo: Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3].
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