Tolcapone
CAS No. : 134308-13-7
(Synonyms: Ro 40-7592)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 50mg | $125 | In-stock |
| 100mg | $165 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-17406 |
| M.Wt: | 273.24 |
| Formula: | C14H11NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4].
IC50 & Target:COMT[1]
α-syn and Aβ42 oligomerization, fibrillogenesis[2]
In Vitro:Tolcapone (10-100 μM, 72 h) inhibits α-synuclein (α-syn) fibrillization[2].
Tolcapone (10-50 μM, 3 h) inhibits α-syn seed-induced polymerization[2].
Tolcapone (5-20 μM, 48 h) inhibits Aβ42 fibrillization[2].
Tolcapone (20 μM, 3 h) inhibits Aβ42 seed-induced polymerization[2].
Tolcapone (5-40 μM, 24 h) protects PC12 cells against α-syn and Aβ42-induced toxicity[2].
Tolcapone (1.5625-400 μM, 48 h) inhibits the viability of SMS-KCNR, SH-SY5Y, BE (2)-C, CHLA-90, MGT-015-08 and MGT9-102-08 neuroblastoma cells, with IC50 values of 32.27-219.8 μM[4].
Tolcapone (1.5625-400 μM, 48 h) inhibits neuroblastoma cell proliferation with GI50 values of 34-130 μM[4].
Tolcapone (25-400 μM, 48 h) induces apoptosis in neuroblastoma cells[4].
Tolcapone (50-100 μM, 1-3 h) increases ROS levels in BE (2)-C and SMS-KCNR cells[4].
Tolcapone (50-200 μM, 48 h) decreases the ATP per cell ratio in neuroblastoma cells[4].
In Vivo:Tolcapone (125 mg/kg, i.g., once daily) inhibits tumor growth and prolongs survival in SMS-KCNR xenograft mice models[4].
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