DCVC
CAS No. : 13419-46-0
(Synonyms: S-[(1E)-1,2-Dichloroethenyl]-L-cysteine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 50mg | $1600 | In-stock |
| 100mg | $2200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19717 |
| M.Wt: | 216.09 |
| Formula: | C5H7Cl2NO2S |
| Purity: | >98 % |
| Solubility: | H2O : 1.034 mg/mL (ultrasonic;warming);DMSO : 2.5 mg/mL (ultrasonic) |
DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures[1][2]. In Vitro: Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner[1].
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