Quilseconazole
CAS No. : 1340593-70-5
(Synonyms: VT-1129)
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1150 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2850 | In-stock |
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| Cat. No. : | HY-109040 |
| M.Wt: | 513.37 |
| Formula: | C22H14F7N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases[1][2][3].
IC50 & Target:Fungal, Cyp51[1]
In Vitro:Quilseconazole exhibits potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii[1].
In Vivo:VT-1129 (0.15-30 mg/kg; oral gavage; 10-14 days) shows antifungal activity in a mouse model of cryptococcal meningitis[2].
Pharmacokinetic Analysis inMale CD-1 Mice[2]
| Route | Dose (mg/kg) | Plasma Cmax | Brain Cmax | Plasma AUC0-96 | Brain AUC0-96 |
| p.o. | 10 | 3.33 μg/mL | 5.24 μg/g | 252 μg·h/mL | 360 μg·h/g |
| p.o. | 100 | 30.8 μg/mL | 42.7 μg/g | 2602 μg·h/mL | 3231 μg·h/g |