Lobeline (hydrochloride)
CAS No. : 134-63-4
(Synonyms: α-Lobeline (hydrochloride); L-Lobeline (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $20 | In-stock |
| 10mg | $25 | In-stock |
| 25mg | $40 | In-stock |
| 50mg | $55 | In-stock |
| 100mg | $99 | In-stock |
| 250mg | $180 | In-stock |
| 500mg | $270 | In-stock |
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| Cat. No. : | HY-B0979 |
| M.Wt: | 373.92 |
| Formula: | C22H28ClNO2 |
| Purity: | >98 % |
| Solubility: | H2O : 6 mg/mL (ultrasonic) |
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation[1][2].
In Vitro:Lobeline (0.1-100 μM) hydrochloride evokes [3H]DA overflow calcium-independently[1].
Lobeline hydrochloride inhibits [3H]DA uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM)[1].
In Vivo:Lobeline (0.3-3.0 mg/kg; s.c.; single dose) hydrochloride decreases d-methamphetamine self-administration in rats model[3].
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) hydrochloride specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3].
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