Diethyltoluamide
CAS No. : 134-62-3
(Synonyms: DEET; N,N-Diethyl-m-toluamide)
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| 1g | $60 | In-stock |
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| Cat. No. : | HY-B0978 |
| M.Wt: | 191.27 |
| Formula: | C12H17NO |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 2 mg/mL (ultrasonic) |
Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction[1][2][3]. In Vitro:Diethyltoluamide (25-250 μM, 24-72h) has toxicity in HepG2 cells[2]. In Vivo:Diethyltoluamide (40 mg/kg was applied directly to the skin, 7 days a week, for 60 days) causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum in rats[3].
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