8-Azaguanine
CAS No. : 134-58-7
| Size | Price | Stock |
|---|---|---|
| 5g | $51 | In-stock |
| 10g | $99 | In-stock |
| 25g | $220 | In-stock |
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| Cat. No. : | HY-B1468 |
| M.Wt: | 152.12 |
| Formula: | C4H4N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;adjust pH to 5 with HCl;heat to 60°C) |
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth[1]. In Vitro:8-Azaguanine induces a decrease in cell viability in a dose, time and cell type dependent manner with MOLT3 cells being the most sensitive to 8-Azaguanine citotoxic effects (24h IC50: 10 μM) when compared with CEM cells (24h IC50: 100 μM). MOLT3 cell treated with 8-Azaguanine shows an increase in CD26 expression (MIF) compared with that of CEM cell submitted to the same conditions (65.4 versus 18.7)[1].
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