Folitixorin (sodium)
CAS No. : 133978-76-4
(Synonyms: 5,10-Methylenetetrafolate (sodium); ANX-510 (sodium))
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| Cat. No. : | HY-14769B |
| M.Wt: | 501.40 |
| Formula: | C20H21N7Na2O6 |
| Purity: | >98 % |
| Solubility: |
Folitixorin sodium (5,10-Methylenetetrafolate sodium; ANX-510 sodium) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin sodium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin sodium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin sodium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer[1][2][3]. In Vitro:Folitixorin (1000 ns) sodium forms structurally conserved stable complexes with human thymidylate synthase and Klebsiella pneumoniae thymidylate synthase [2]. In Vivo:Folitixorin (0.6 mg/mouse; i.p.; once daily for five consecutive days) sodium in combination with 5‑Fluorouracil and αVEGF reduces tumor volume and improves survival rate in a colorectal tumor model of nude mice[3].
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