2-Iminobiotin
CAS No. : 13395-35-2
(Synonyms: Guanidinobiotin)
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|---|---|---|
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| 25mg | $40 | In-stock |
| 50mg | $60 | In-stock |
| 100mg | $96 | In-stock |
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| Cat. No. : | HY-118700 |
| M.Wt: | 243.33 |
| Formula: | C10H17N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2]. IC50 & Target:NO synthases[1] In Vitro: Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control[1].
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